Synthesis of 4-nitroimidazole has been discussed in this paper. The neutral reaction of imidazole with concentrated sulfuric acid produces disulfuric imidazole salt, which can then be converted to 4-nitroimidazole by nitration reaction with mixed acids of sulfuric acid and nitric acid. 研究了4-硝基咪唑的合成,即咪唑先和浓硫酸发生酸碱中和反应生成二硫酸咪唑盐,硝-硫混酸硝化二硫酸咪唑盐合成4-硝基咪唑。